ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CASP10

Full Name:

caspase 10, apoptosis-related cysteine peptidase

Alias:

ALPS2|FLICE2|MCH4

Organism:

Homo sapiens (Human)

Chromosome:

2

Genetic Location:

2q33-q34

Physical Location:

201755865-201802354 on NC_000002.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S117

195326948

Region:		195326948-216757195
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001230.4	NP_001221.2	NC_000002.10 range: 201755865..201802354
NM_032974.3	NP_116756.2	NC_000002.10 range: 201755865..201802354
NM_032977.3	NP_116759.2	NC_000002.10 range: 201755865..201802354

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005515	protein binding	Molecular Function	IEA
GO:0008234	cysteine-type peptidase activity	Molecular Function	IEA
GO:0030693	caspase activity	Molecular Function	IEA
GO:0030693	caspase activity	Molecular Function	TAS (8755496\|10412980)
GO:0042802	identical protein binding	Molecular Function	IPI (11717445)
GO:0006508	proteolysis	Biological Process	IEA
GO:0008624	induction of apoptosis by extracellular signals	Biological Process	EXP (11048727)
GO:0042981	regulation of apoptosis	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000003400

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: