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Gene Information
Gene ID:84433
Symbol:CARD11
Full Name:caspase recruitment domain family, member 11
Alias:BIMP3|CARMA1|MGC133069
Organism:Homo sapiens (Human)
Chromosome:7
Genetic Location:7p22
Physical Location:2912294-3050104 on NC_000007.12, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D7S517  4464441
Region:2464441-6464441
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_032415.3NP_115791.3NC_000007.12 range: 2912294..3050104, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentIDA (12154360)
GO:0005622intracellularCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIDA (12154360)
GO:0005829cytosolCellular ComponentEXP (15122200|15125833|15541657|17468049)
GO:0042101T cell receptor complexCellular ComponentIDA (12154360)
GO:0045121membrane raftCellular ComponentIDA (12154360)
GO:0004385guanylate kinase activityMolecular FunctionNAS (11278692)
GO:0005515protein bindingMolecular FunctionIPI (16809782)
GO:0050700CARD domain bindingMolecular FunctionIPI (11278692)
GO:0042981regulation of apoptosisBiological ProcessIEA
GO:0001819positive regulation of cytokine productionBiological ProcessIMP (12154360)
GO:0051092activation of NF-kappaB transcription factorBiological ProcessIMP (12154360)
Other Database Cross Links
NCBI Entrez Gene:84433
HGNC:16393
Ensembl:ENSG00000198286
MIM:607210
HPRD:06234
HuGE Navigator:84433
dbSNP:CARD11
GeneCard:CARD11
AceView:CARD11