| Gene Information |
| Gene ID: | | 8567 |
| Symbol: | | MADD |
| Full Name: | | MAP-kinase activating death domain |
| Alias: | | DENN|IG20|KIAA0358|RAB3GEP |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 11 |
| Genetic Location: | | 11p11.2 |
| Physical Location: | | 47247534-47308157 on NC_000011.8 |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | | Dataset Information | | Name: | | Literature Search | | Method: | | Literature search | | Summary: | | We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005886 | plasma membrane | Cellular Component | TAS (8988362) | |
| GO:0016021 | integral to membrane | Cellular Component | IDA (8988362) | |
| GO:0005737 | cytoplasm | Cellular Component | TAS (8988362) | |
| GO:0017112 | Rab guanyl-nucleotide exchange factor activity | Molecular Function | IMP (9115275) | |
| GO:0030295 | protein kinase activator activity | Molecular Function | TAS (9115275) | |
| GO:0005515 | protein binding | Molecular Function | IPI (9115275) | |
| GO:0005123 | death receptor binding | Molecular Function | TAS (9115275) | |
| GO:0005085 | guanyl-nucleotide exchange factor activity | Molecular Function | IEA | |
| GO:0042981 | regulation of apoptosis | Biological Process | IMP (9115275|11577081|14735464) | |
| GO:0000187 | activation of MAPK activity | Biological Process | IMP (9115275) | |
| GO:0007166 | cell surface receptor linked signal transduction | Biological Process | TAS (9115275) | |
| GO:0051726 | regulation of cell cycle | Biological Process | IMP (14735464) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 8567 |
| HGNC: | | 6766 |
| Ensembl: | | ENSG00000110514 |
| MIM: | | 603584 |
| HPRD: | | 04664 |
| HuGE Navigator: | | 8567 |
| dbSNP: | | MADD |
| GeneCard: | | MADD |
| AceView: | | MADD |
