ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CASK

Full Name:

calcium/calmodulin-dependent serine protein kinase (MAGUK family)

Alias:

CMG|LIN2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

Xp11.4

Physical Location:

41264286-41667211 on NC_000023.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

CASK

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003688.2	NP_003679.2	NC_000023.9 range: 41264286..41667211, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0015629	actin cytoskeleton	Cellular Component	TAS (9660868)
GO:0005886	plasma membrane	Cellular Component	TAS (9660868)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005516	calmodulin binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004385	guanylate kinase activity	Molecular Function	TAS (9660868)
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0007155	cell adhesion	Biological Process	TAS (9660868)