ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TNFRSF10A

Full Name:

tumor necrosis factor receptor superfamily, member 10a

Alias:

APO2|CD261|DR4|MGC9365|TRAILR-1|TRAILR1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

8p21

Physical Location:

23104914-23138583 on NC_000008.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

TNFRSF10A

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003844.2	NP_003835.2	NC_000008.9 range: 23104914..23138583, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IC (9311998)
GO:0016020	membrane	Cellular Component	IEA
GO:0004872	receptor activity	Molecular Function	NAS (9311998)
GO:0008656	caspase activator activity	Molecular Function	NAS
GO:0045569	TRAIL binding	Molecular Function	NAS (9373179)
GO:0005035	death receptor activity	Molecular Function	TAS (9082980)
GO:0007165	signal transduction	Biological Process	TAS (9082980)
GO:0006919	caspase activation	Biological Process	NAS
GO:0008625	induction of apoptosis via death domain receptors	Biological Process	NAS (9311998)
GO:0006917	induction of apoptosis	Biological Process	NAS (9311998)
GO:0006915	apoptosis	Biological Process	IEA
GO:0007250	activation of NF-kappaB-inducing kinase activity	Biological Process	NAS (9430227\|11464292)