ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CREG1

Full Name:

cellular repressor of E1A-stimulated genes 1

Alias:

CREG

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1q24

Physical Location:

165776873-165789679 on NC_000001.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 433375 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D1S2878

163669990

Region:		163669990-165871089
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003851.2	NP_003842.1	NC_000001.9 range: 165776873..165789679, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0003702	RNA polymerase II transcription factor activity	Molecular Function	TAS (9710587)
GO:0003714	transcription corepressor activity	Molecular Function	TAS (9710587)
GO:0001558	regulation of cell growth	Biological Process	IEA
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS (9710587)
GO:0007275	multicellular organismal development	Biological Process	TAS (9710587)
GO:0008283	cell proliferation	Biological Process	TAS (9710587)