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Gene Information
Gene ID:8828
Symbol:NRP2
Full Name:neuropilin 2
Alias:MGC126574|NP2|NPN2|PRO2714|VEGF165R2
Organism:Homo sapiens (Human)
Chromosome:2
Genetic Location:2q33.3
Physical Location:206255468-206371101 on NC_000002.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D2S117  195326948
Region:195326948-216757195
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003872.2NP_003863.2NC_000002.10 range: 206255468..206371101
NM_018534.3NP_061004.3NC_000002.10 range: 206255468..206371101
NM_201264.1NP_957716.1NC_000002.10 range: 206255468..206371101
NM_201266.1NP_957718.1NC_000002.10 range: 206255468..206371101
NM_201267.1NP_957719.1NC_000002.10 range: 206255468..206371101
NM_201279.1NP_958436.1NC_000002.10 range: 206255468..206371101
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentNAS (11112349)
GO:0005886plasma membraneCellular ComponentEXP (11278319)
GO:0005624membrane fractionCellular ComponentTAS (9288754)
GO:0005021vascular endothelial growth factor receptor activityMolecular FunctionTAS (9331348)
GO:0017154semaphorin receptor activityMolecular FunctionNAS (11112349)
GO:0005021vascular endothelial growth factor receptor activityMolecular FunctionNAS (11112349)
GO:0004872receptor activityMolecular FunctionTAS (9288754)
GO:0030154cell differentiationBiological ProcessIEA
GO:0001525angiogenesisBiological ProcessNAS (11112349)
GO:0007411axon guidanceBiological ProcessTAS (9288754)
GO:0007399nervous system developmentBiological ProcessIEA
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0007155cell adhesionBiological ProcessNAS (11112349)
GO:0007155cell adhesionBiological ProcessIEA
GO:0045454cell redox homeostasisBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:8828
HGNC:8005
Ensembl:ENSG00000118257
MIM:602070
HPRD:03643
HuGE Navigator:8828
dbSNP:NRP2
GeneCard:NRP2
AceView:NRP2