ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PRPF4B

Full Name:

PRP4 pre-mRNA processing factor 4 homolog B (yeast)

Alias:

KIAA0536|PR4H|PRP4|PRP4H|PRP4K|dJ1013A10.1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

6p25.2

Physical Location:

3966567-4010215 on NC_000006.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D6S1574

5957132

Region:		3957132-7957132
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003913.4	NP_003904.3	NC_000006.10 range: 3966567..4010215

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005681	spliceosome	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15452250\|16169070\|17513757)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0006397	mRNA processing	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	TAS (9102632)
GO:0008380	RNA splicing	Biological Process	TAS (9102632)