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Gene Information
Gene ID:891
Symbol:CCNB1
Full Name:cyclin B1
Alias:CCNB
Organism:Homo sapiens (Human)
Chromosome:5
Genetic Location:5q12
Physical Location:68498668-68509827 on NC_000005.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D5S647  66282906
Region:66282906-76193808
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031966.2NP_114172.1NC_000005.8 range: 68498668..68509827
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005813centrosomeCellular ComponentIEA
GO:0005829cytosolCellular ComponentEXP (1717476|10395539|11285280)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005654nucleoplasmCellular ComponentEXP (1384126|1828290|7799941|10395539|11598127|12791267)
GO:0005634nucleusCellular ComponentIEA
GO:0005634nucleusCellular ComponentIDA (16109376)
GO:0005575cellular_componentCellular ComponentND
GO:0005515protein bindingMolecular FunctionIPI (8756624|9001210|10373560)
GO:0051301cell divisionBiological ProcessIEA
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processBiological ProcessEXP (11285280)
GO:0007067mitosisBiological ProcessIEA
GO:0007049cell cycleBiological ProcessIEA
GO:0000086G2/M transition of mitotic cell cycleBiological ProcessNAS
GO:0051437positive regulation of ubiquitin-protein ligase activity during mitotic cell cycleBiological ProcessEXP (10793135)
Other Database Cross Links
NCBI Entrez Gene:891
HGNC:1579
Ensembl:ENSG00000134057
MIM:123836
HPRD:00454
HuGE Navigator:891
dbSNP:CCNB1
GeneCard:CCNB1
AceView:CCNB1