ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SLC16A3

Full Name:

solute carrier family 16, member 3 (monocarboxylic acid transporter 4)

Alias:

MCT3|MCT4|MGC138472|MGC138474

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q25

Physical Location:

77779581-77790657 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S928

77846128

Region:		75846128-78774742
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005624	membrane fraction	Cellular Component	TAS (9425115)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	TAS (9425115)
GO:0005215	transporter activity	Molecular Function	IEA
GO:0015293	symporter activity	Molecular Function	IEA
GO:0015355	secondary active monocarboxylate transmembrane transporter activity	Molecular Function	IEA
GO:0006810	transport	Biological Process	IEA
GO:0015711	organic anion transport	Biological Process	IEA
GO:0015718	monocarboxylic acid transport	Biological Process	TAS (9425115)