ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CD247

Full Name:

CD247 molecule

Alias:

CD3-ZETA|CD3H|CD3Q|CD3Z|T3Z|TCRZ

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1q22-q23

Physical Location:

165666504-165754449 on NC_000001.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 12503 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D1S2878

163669990

Region:		163669990-165871089
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0042101	T cell receptor complex	Cellular Component	IDA (8176201)
GO:0005737	cytoplasm	Cellular Component	IDA (11390434)
GO:0005886	plasma membrane	Cellular Component	EXP (11048639\|11827988\|15489916\|17652306)
GO:0005886	plasma membrane	Cellular Component	IDA (1390434\|11390434)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0004888	transmembrane receptor activity	Molecular Function	IEA
GO:0042803	protein homodimerization activity	Molecular Function	NAS (12110186)
GO:0005057	receptor signaling protein activity	Molecular Function	NR
GO:0007166	cell surface receptor linked signal transduction	Biological Process	IEA