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Gene Information
Gene ID:9201
Symbol:DCLK1
Full Name:doublecortin-like kinase 1
Alias:DCAMKL1|DCDC3A|DCLK|KIAA0369
Organism:Homo sapiens (Human)
Chromosome:13
Genetic Location:13q13
Physical Location:35243477-35603442 on NC_000013.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D13S171  32151912
Region:32151912-40979230
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_004734.2NP_004725.1NC_000013.9 range: 35243477..35603442, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005887integral to plasma membraneCellular ComponentTAS (10036192)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0004674protein serine/threonine kinase activityMolecular FunctionIEA
GO:0005057receptor signaling protein activityMolecular FunctionTAS (10036192)
GO:0005515protein bindingMolecular FunctionNAS (14613930)
GO:0005524ATP bindingMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0016301kinase activityMolecular FunctionIEA
GO:0016197endosome transportBiological ProcessNAS (14613930)
GO:0007417central nervous system developmentBiological ProcessTAS (10051403)
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0007242intracellular signaling cascadeBiological ProcessIEA
GO:0006468protein amino acid phosphorylationBiological ProcessTAS (9747029)
GO:0030154cell differentiationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:9201
HGNC:2700
Ensembl:ENSG00000133083
MIM:604742
HPRD:09202
HuGE Navigator:9201
dbSNP:DCLK1
GeneCard:DCLK1
AceView:DCLK1