ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

DCLK1

Full Name:

doublecortin-like kinase 1

Alias:

DCAMKL1|DCDC3A|DCLK|KIAA0369

Organism:

Homo sapiens (Human)

Chromosome:

13

Genetic Location:

13q13

Physical Location:

35243477-35603442 on NC_000013.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D13S171

32151912

Region:		32151912-40979230
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004734.2	NP_004725.1	NC_000013.9 range: 35243477..35603442, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (10036192)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0005057	receptor signaling protein activity	Molecular Function	TAS (10036192)
GO:0005515	protein binding	Molecular Function	NAS (14613930)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0016197	endosome transport	Biological Process	NAS (14613930)
GO:0007417	central nervous system development	Biological Process	TAS (10051403)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007242	intracellular signaling cascade	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	TAS (9747029)
GO:0030154	cell differentiation	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000133083

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: