ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

LRRFIP1

Full Name:

leucine rich repeat (in FLII) interacting protein 1

Alias:

FLAP-1|FLIIAP1|GCF-2|GCF2|HUFI-1|MGC10947|MGC119738|MGC119739|TRIP

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q37.3

Physical Location:

238265667-238338644 on NC_000002.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S2973

2.20

0.0007

235696080

D2S140

1.95

0.0014

241388318

Region:		235696080-241388318
Phenotype:		WDSFS (withdrawal symptoms factor score)
Name:		17067344
Method:		Linkage
Publication:		Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
Summary:		A 4-cM dense whole-genome linkage study was conducted in the Irish Affected Sib Pair Study of Alcohol Dependence. Probands, affected siblings, and parents were evaluated by structured interview. Variance component linkage analysis was applied to data from 485 families for 5 measures: initial sensitivity and tolerance (based on scales from the self-report of the effects of ethanol; maximum drinks within 24 hours, an empirically derived factor score based on withdrawal symptoms, and age at onset of alcohol dependence.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004735.2	NP_004726.1	NC_000002.10 range: 238265667..238338644

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	NAS (9705290)
GO:0005856	cytoskeleton	Cellular Component	TAS (9671805)
GO:0005737	cytoplasm	Cellular Component	TAS (9671805)
GO:0005575	cellular_component	Cellular Component	ND
GO:0003674	molecular_function	Molecular Function	ND
GO:0005515	protein binding	Molecular Function	IPI (9671805)
GO:0003725	double-stranded RNA binding	Molecular Function	TAS (9671805)
GO:0003702	RNA polymerase II transcription factor activity	Molecular Function	NR
GO:0003677	DNA binding	Molecular Function	IEA
GO:0016564	transcription repressor activity	Molecular Function	NAS (9705290)
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS (9705290)
GO:0008150	biological_process	Biological Process	ND
GO:0016481	negative regulation of transcription	Biological Process	NAS (9705290)