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Gene Information
Gene ID:9218
Symbol:VAPA
Full Name:VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
Alias:MGC3745|VAP-33|VAP-A|VAP33|hVAP-33
Organism:Homo sapiens (Human)
Chromosome:18
Genetic Location:18p11.22
Physical Location:9903954-9950017 on NC_000018.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D18S53  11482730
Region:9482730-13482730
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003574.5NP_003565.4NC_000018.8 range: 9903954..9950017
NM_194434.2NP_919415.2NC_000018.8 range: 9903954..9950017
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0048471perinuclear region of cytoplasmCellular ComponentIDA (16895911)
GO:0031982vesicleCellular ComponentIDA (10523508)
GO:0016021integral to membraneCellular ComponentIEA
GO:0012505endomembrane systemCellular ComponentIEA
GO:0005923tight junctionCellular ComponentIDA (10523508)
GO:0005886plasma membraneCellular ComponentIDA (10523508)
GO:0005515protein bindingMolecular FunctionIPI (16895911)
GO:0005198structural molecule activityMolecular FunctionIEA
GO:0046982protein heterodimerization activityMolecular FunctionIPI (9920726|16227268)
GO:0004871signal transducer activityMolecular FunctionIMP (12761501)
GO:0006944membrane fusionBiological ProcessTAS (9657962)
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeBiological ProcessIMP (12761501)
Other Database Cross Links
NCBI Entrez Gene:9218
HGNC:12648
Ensembl:ENSG00000101558
MIM:605703
HPRD:09299
HuGE Navigator:9218
dbSNP:VAPA
GeneCard:VAPA
AceView:VAPA