ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CD8A

Full Name:

CD8a molecule

Alias:

CD8|Leu2|MAL|p32

Organism:

Homo sapiens (Human)

Chromosome:

2

Genetic Location:

2p12

Physical Location:

86865238-86871637 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

CD8A

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

Original ID	No. of Publications	Phenotype
CD8A	1	Alcoholism

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001768.5	NP_001759.3	NC_000002.10 range: 86865238..86871637, complement
NM_171827.2	NP_741969.1	NC_000002.10 range: 86865238..86871637, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	NAS (2496167)
GO:0042101	T cell receptor complex	Cellular Component	NAS (11131152)
GO:0005515	protein binding	Molecular Function	IPI (2470098\|2493728)
GO:0015026	coreceptor activity	Molecular Function	NAS (11131152)
GO:0042288	MHC class I protein binding	Molecular Function	NAS (11131152)
GO:0019882	antigen processing and presentation	Biological Process	NAS (2496167)
GO:0006955	immune response	Biological Process	NAS (11131152)
GO:0042110	T cell activation	Biological Process	NAS (9830036)
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	NAS (9830036)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000153563

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: