ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RPS6KA5

Full Name:

ribosomal protein S6 kinase, 90kDa, polypeptide 5

Alias:

MGC1911|MSK1|MSPK1|RLPK

Organism:

Homo sapiens (Human)

Chromosome:

14

Genetic Location:

14q31-q32.1

Physical Location:

90406911-90596745 on NC_000014.7, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AW968068
Fold Change:		0.69
P Value:		7.00E-03
Tissue:		Prefrontal cortex

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004755.2	NP_004746.2	NC_000014.7 range: 90406911..90596745, complement
NM_182398.1	NP_872198.1	NC_000014.7 range: 90406911..90596745, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005654	nucleoplasm	Cellular Component	EXP (9687510)
GO:0005634	nucleus	Cellular Component	IEP (9687510)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IDA (9687510)
GO:0005515	protein binding	Molecular Function	IPI (12628924)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA (9687510)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	EXP (9687510)
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0008237	metallopeptidase activity	Molecular Function	IEA
GO:0016572	histone phosphorylation	Biological Process	IDA (9873047)
GO:0009605	response to external stimulus	Biological Process	IEP (9873047)
GO:0007243	protein kinase cascade	Biological Process	IDA (9687510)
GO:0007173	epidermal growth factor receptor signaling pathway	Biological Process	TAS (9873047)
GO:0006950	response to stress	Biological Process	IEP (9873047)
GO:0006508	proteolysis	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IDA (9687510)
GO:0042221	response to chemical stimulus	Biological Process	IEP (9873047)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000100784

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: