ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

STK17B

Full Name:

serine/threonine kinase 17b

Alias:

DRAK2

Organism:

Homo sapiens (Human)

Chromosome:

2

Genetic Location:

2q32.3

Physical Location:

196710101-196744519 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S117

195326948

Region:		195326948-216757195
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004226.2	NP_004217.1	NC_000002.10 range: 196710101..196744519, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEP (9786912)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA (9786912)
GO:0005524	ATP binding	Molecular Function	IDA (9786912)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (9786912)
GO:0006915	apoptosis	Biological Process	IEA
GO:0006917	induction of apoptosis	Biological Process	IMP (9786912)
GO:0007243	protein kinase cascade	Biological Process	IDA (9786912)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000081320

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: