ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PSCD3

Full Name:

pleckstrin homology, Sec7 and coiled-coil domains 3

Alias:

ARNO3|GRP1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

7p22.1

Physical Location:

6167934-6278766 on NC_000007.12, complement

Gene Type:

protein-coding

Orthologs:

This gene has Worm: 176140 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D7S517

4464441

Region:		2464441-6464441
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004227.3	NP_004218.1	NC_000007.12 range: 6167934..6278766, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	TAS (9742223)
GO:0005886	plasma membrane	Cellular Component	TAS (9742223)
GO:0005086	ARF guanyl-nucleotide exchange factor activity	Molecular Function	TAS (9707577)
GO:0005545	phosphatidylinositol binding	Molecular Function	TAS (9742223)
GO:0008095	inositol-1,4,5-triphosphate receptor activity	Molecular Function	TAS (9742223)
GO:0016192	vesicle-mediated transport	Biological Process	TAS (9707577)
GO:0032012	regulation of ARF protein signal transduction	Biological Process	IEA