ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GLP2R

Full Name:

glucagon-like peptide 2 receptor

Organism:

Homo sapiens (Human)

Chromosome:

17

Genetic Location:

17p13.3

Physical Location:

9670105-9733746 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S1852

10456226

Region:		8456226-12456226
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004246.1	NP_004237.1	NC_000017.9 range: 9670105..9733746

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	TAS (9990065)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	TAS (9990065)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004930	G-protein coupled receptor activity	Molecular Function	TAS (9990065)
GO:0004930	G-protein coupled receptor activity	Molecular Function	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	Biological Process	TAS (9990065)
GO:0008284	positive regulation of cell proliferation	Biological Process	TAS (9990065)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000065325

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: