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Gene Information
Gene ID:9365
Full Name:klotho
Organism:Homo sapiens (Human)
Genetic Location:13q12
Physical Location:32488570-32538278 on NC_000013.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:KL
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D13S171  32151912
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_004795.2NP_004786.2NC_000013.9 range: 32488570..32538278
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentEXP (17086194)
GO:0005887integral to plasma membraneCellular ComponentTAS (9464267)
GO:0005886plasma membraneCellular ComponentIEA
GO:0005576extracellular regionCellular ComponentEXP (17086194)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentTAS (9464267)
GO:0005624membrane fractionCellular ComponentTAS (9464267)
GO:0005625soluble fractionCellular ComponentTAS (9464267)
GO:0008422beta-glucosidase activityMolecular FunctionTAS (9363890)
GO:0004566beta-glucuronidase activityMolecular FunctionIEA
GO:0005499vitamin D bindingMolecular FunctionIEA
GO:0005179hormone activityMolecular FunctionIEA
GO:0004871signal transducer activityMolecular FunctionTAS (9363890)
GO:0043169cation bindingMolecular FunctionIEA
GO:0005975carbohydrate metabolic processBiological ProcessIEA
GO:0007568agingBiological ProcessIMP (11792841)
GO:0008152metabolic processBiological ProcessIEA
GO:0008543fibroblast growth factor receptor signaling pathwayBiological ProcessEXP (17086194)
GO:0030501positive regulation of bone mineralizationBiological ProcessIMP (12110410)
Other Database Cross Links
NCBI Entrez Gene:9365
HuGE Navigator:9365