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Gene Information
Gene ID:939
Full Name:CD27 molecule
Organism:Homo sapiens (Human)
Genetic Location:12p13
Physical Location:6424311-6431144 on NC_000012.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CD27
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D12S99  5434815
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001242.4NP_001233.1NC_000012.10 range: 6424311..6431144
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000786nucleosomeCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentNAS (12324477)
GO:0005634nucleusCellular ComponentIEA
GO:0005576extracellular regionCellular ComponentNAS (12624711)
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIPI (12324477)
GO:0004888transmembrane receptor activityMolecular FunctionNAS (14556986)
GO:0043027caspase inhibitor activityMolecular FunctionIDA (12324477)
GO:0003677DNA bindingMolecular FunctionIEA
GO:0045579positive regulation of B cell differentiationBiological ProcessNAS (10809378)
GO:0016064immunoglobulin mediated immune responseBiological ProcessNAS (14556986)
GO:0008588release of cytoplasmic sequestered NF-kappaBBiological ProcessNAS (12324477)
GO:0007283spermatogenesisBiological ProcessIEA
GO:0007166cell surface receptor linked signal transductionBiological ProcessNAS (14556986)
GO:0006955immune responseBiological ProcessIEA
GO:0006917induction of apoptosisBiological ProcessISS
GO:0006916anti-apoptosisBiological ProcessISS
GO:0006916anti-apoptosisBiological ProcessIDA (12324477)
GO:0006915apoptosisBiological ProcessIEA
GO:0046330positive regulation of JNK cascadeBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:939
HuGE Navigator:939