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Gene Information
Gene ID:9414
Symbol:TJP2
Full Name:tight junction protein 2 (zona occludens 2)
Alias:MGC26306|X104|ZO-2|ZO2
Organism:Homo sapiens (Human)
Chromosome:9
Genetic Location:9q13-q21
Physical Location:70978908-71059939 on NC_000009.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:L27476
Fold Change:-1.4, -1.6
Note:Differential Expression on the cDNA array (two fold changes are from two case groups)
Dataset Information
Name:11141048
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_004817.2NP_004808.2NC_000009.10 range: 70978908..71059939
NM_201629.1NP_963923.1NC_000009.10 range: 70978908..71059939
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentNR
GO:0005923tight junctionCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0030054cell junctionCellular ComponentIEA
GO:0004385guanylate kinase activityMolecular FunctionTAS (8824195)
GO:0005515protein bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (17353931)
Other Database Cross Links
NCBI Entrez Gene:9414
HGNC:11828
Ensembl:ENSG00000119139
MIM:607709
HPRD:06369
HuGE Navigator:9414
dbSNP:TJP2
GeneCard:TJP2
AceView:TJP2