ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SLC25A27

Full Name:

solute carrier family 25, member 27

Alias:

FLJ33552|UCP4

Organism:

Homo sapiens (Human)

Chromosome:

6

Genetic Location:

6p11.2-q12

Physical Location:

46728637-46753885 on NC_000006.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene SNP Information

SNP	Abuser/Control Ratio	Cluster
rs953062 dbSNP	0.77	24

Association Dataset

Name:		16894614
Method:		Association
Publication:		Johnson et al. Am J Med Genet B Neuropsychiatr Genet. (2006) Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. PubMed
Summary:		Association genome scanning can identify markers for the allelic variants that contribute to vulnerability to complex disorders, including alcohol dependence. To improve the power and feasibility of this approach, we report validation of 100k microarray-based allelic frequency assessments in pooled DNA samples. We then use this approach with unrelated alcohol-dependent versus control individuals sampled from pedigrees collected by the Collaborative Study on the Genetics of Alcoholism (COGA). Allele frequency differences between alcohol-dependent and control individuals are assessed in quadruplicate at 104,268 autosomal SNPs in pooled samples. One hundred eighty-eight SNPs provide (1) the largest allele frequency differences between dependent versus control individuals; (2) t values 3 for these differences; and (3) clustering, so that 51 relatively small chromosomal regions contain at least three SNPs that satisfy criteria 1 and 2 above (Monte Carlo P = 0.00034).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004277.3	NP_004268.3	NC_000006.10 range: 46728637..46753885

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	TAS (10025957)
GO:0005743	mitochondrial inner membrane	Cellular Component	IEA
GO:0005743	mitochondrial inner membrane	Cellular Component	NAS (10025957)
GO:0005215	transporter activity	Molecular Function	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006839	mitochondrial transport	Biological Process	IEA
GO:0006091	generation of precursor metabolites and energy	Biological Process	TAS (10025957)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000153291

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: