ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PIGL

Full Name:

phosphatidylinositol glycan anchor biosynthesis, class L

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17p12-p11.2

Physical Location:

16061233-16170297 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S1857

16355942

Region:		14355942-18355942
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004278.3	NP_004269.1	NC_000017.9 range: 16061233..16170297

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005783	endoplasmic reticulum	Cellular Component	NAS
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0000225	N-acetylglucosaminylphosphatidylinositol deacetylase activity	Molecular Function	NAS (10085243)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0016254	preassembly of GPI anchor in ER membrane	Biological Process	EXP (11102867)