ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SLC4A7

Full Name:

solute carrier family 4, sodium bicarbonate cotransporter, member 7

Alias:

DKFZp686H168|NBC2|NBC3|SBC2|SLC4A6

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

3p22

Physical Location:

27389217-27473248 on NC_000003.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

SLC4A7

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

Original ID	No. of Publications	Phenotype
SLC4A7	1	Alcoholism

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003615.3	NP_003606.3	NC_000003.10 range: 27389217..27473248, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0042995	cell projection	Cellular Component	IEA
GO:0016324	apical plasma membrane	Cellular Component	IEA
GO:0016323	basolateral plasma membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	NAS (10347222)
GO:0016020	membrane	Cellular Component	IEA
GO:0031402	sodium ion binding	Molecular Function	IEA
GO:0015293	symporter activity	Molecular Function	IEA
GO:0008510	sodium:bicarbonate symporter activity	Molecular Function	NAS (10347222)
GO:0008509	anion transmembrane transporter activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0005452	inorganic anion exchanger activity	Molecular Function	IEA
GO:0005215	transporter activity	Molecular Function	IEA
GO:0015701	bicarbonate transport	Biological Process	NAS (10347222)
GO:0006820	anion transport	Biological Process	IEA
GO:0006814	sodium ion transport	Biological Process	IEA