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Gene Information
Gene ID:9759
Symbol:HDAC4
Full Name:histone deacetylase 4
Alias:HA6116|HD4|HDAC-A|HDACA|KIAA0288
Organism:Homo sapiens (Human)
Chromosome:2
Genetic Location:2q37.3
Physical Location:239634800-239987579 on NC_000002.10, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D2S29732.200.0007235696080
D2S1401.950.0014241388318
Region:235696080-241388318
Phenotype:WDSFS (withdrawal symptoms factor score)
Name:17067344
Method:Linkage
Publication:Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
Summary:A 4-cM dense whole-genome linkage study was conducted in the Irish Affected Sib Pair Study of Alcohol Dependence. Probands, affected siblings, and parents were evaluated by structured interview. Variance component linkage analysis was applied to data from 485 families for 5 measures: initial sensitivity and tolerance (based on scales from the self-report of the effects of ethanol; maximum drinks within 24 hours, an empirically derived factor score based on withdrawal symptoms, and age at onset of alcohol dependence.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_006037.3NP_006028.2NC_000002.10 range: 239634800..239987579, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000118histone deacetylase complexCellular ComponentTAS (12711221)
GO:0005634nucleusCellular ComponentNAS
GO:0005737cytoplasmCellular ComponentTAS (12711221)
GO:0004407histone deacetylase activityMolecular FunctionNAS (10523670)
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0016564transcription repressor activityMolecular FunctionTAS (10523670)
GO:0008134transcription factor bindingMolecular FunctionTAS (12711221)
GO:0030183B cell differentiationBiological ProcessTAS (12711221)
GO:0016568chromatin modificationBiological ProcessTAS (12711221)
GO:0007399nervous system developmentBiological ProcessTAS (12711221)
GO:0007275multicellular organismal developmentBiological ProcessNAS
GO:0007049cell cycleBiological ProcessNAS
GO:0006954inflammatory responseBiological ProcessTAS (12711221)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessTAS (10523670)
GO:0006350transcriptionBiological ProcessIEA
GO:0045843negative regulation of striated muscle developmentBiological ProcessTAS (12711221)
Other Database Cross Links
NCBI Entrez Gene:9759
HGNC:14063
Ensembl:ENSG00000068024
MIM:605314
HPRD:05610
HuGE Navigator:9759
dbSNP:HDAC4
GeneCard:HDAC4
AceView:HDAC4