ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SEC24D

Full Name:

SEC24 related gene family, member D (S. cerevisiae)

Alias:

FLJ43974|KIAA0755

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

4q26

Physical Location:

119863426-119976701 on NC_000004.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D4S423

2.61

0.0003

92691777

D4S427

3.53

0.00003

121646580

Region:		92691777-121646580
Phenotype:		ADSX (number of DSM-IV AD symptoms)
Name:		16534506
Method:		Linkage
Publication:		Prescott et al. Mol Psychiatry. (2006) Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. PubMed
Summary:		We conducted a genome scan in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). A 4 cM genome scan was conducted using 474 families of which most (96%) were comprised by affected sib pairs. Nonparametric and quantitative linkage analyses were conducted using DSM-IV alcohol dependence (AD) and number of DSM-IV AD symptoms (ADSX). Quantitative results indicate strong linkage for number of AD criteria to a broad region of chromosome 4, ranging from 4q22 to 4q32 (peak multipoint LOD=4.59, P=2.1 x 10(-6), at D4S1611). We got the gene list in the region between two markers D4S423 and D4S427 as markers between (included) these two markers have LOD scores >2 with P value <0.0003.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_014822.2	NP_055637.2	NC_000004.10 range: 119863426..119976701, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030127	COPII vesicle coat	Cellular Component	NAS (10329445)
GO:0030127	COPII vesicle coat	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0003674	molecular_function	Molecular Function	ND
GO:0005515	protein binding	Molecular Function	IEA
GO:0006888	ER to Golgi vesicle-mediated transport	Biological Process	EXP (11252894)
GO:0006888	ER to Golgi vesicle-mediated transport	Biological Process	NAS (10329445)
GO:0006886	intracellular protein transport	Biological Process	IEA
GO:0016044	membrane organization and biogenesis	Biological Process	EXP (11031247)
GO:0016192	vesicle-mediated transport	Biological Process	IEA
GO:0006888	ER to Golgi vesicle-mediated transport	Biological Process	IEA