| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10059660 | HBV | ENSG00000130005.13 | protein_coding | GAMT | No | No | 2593 | Q14353 |
| TVIS10059193 | HBV | ENSG00000130005.13 | protein_coding | GAMT | No | No | 2593 | Q14353 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | GAMT |
|---|---|
| DrugBank ID | DB00148 |
| Drug Name | Creatine |
| Target ID | BE0000567 |
| UniProt ID | Q14353 |
| Regulation Type | product of |
| PubMed IDs | 17336114; 17347380; 17486546 |
| Citations | Almeida LS, Vilarinho L, Darmin PS, Rosenberg EH, Martinez-Munoz C, Jakobs C, Salomons GS: A prevalent pathogenic GAMT mutation (c.59G>C) in Portugal. Mol Genet Metab. 2007 May;91(1):1-6. Epub 2007 Mar 1.@@Kan HE, Meeuwissen E, van Asten JJ, Veltien A, Isbrandt D, Heerschap A: Creatine uptake in brain and skeletal muscle of mice lacking guanidinoacetate methyltransferase assessed by magnetic resonance spectroscopy. J Appl Physiol (1985). 2007 Jun;102(6):2121-7. Epub 2007 Mar 8.@@Wang L, Zhang Y, Shao M, Zhang H: Spatiotemporal expression of the creatine metabolism related genes agat, gamt and ct1 during zebrafish embryogenesis. Int J Dev Biol. 2007;51(3):247-53. |
| Groups | Approved; Investigational; Nutraceutical |
| Direct Classification | Alpha amino acids and derivatives |
| SMILES | CN(CC(O)=O)C(N)=N |
| Pathways | Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency); Hyperornithinemia with Gyrate Atrophy (HOGA); Hyperprolinemia Type II; 3-Phosphoglycerate Dehydrogenase Deficiency; Non-Ketotic Hyperglycinemia; L-Arginine:Glycine Amidinotransferase Deficiency; Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome]; Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency); Prolidase Deficiency (PD); Glycine and Serine Metabolism; Hyperglycinemia, Non-Ketotic; Dimethylglycine Dehydrogenase Deficiency; Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency; Ornithine Aminotransferase Deficiency (OAT Deficiency); Hyperprolinemia Type I; Dihydropyrimidine Dehydrogenase Deficiency (DHPD); Arginine and Proline Metabolism; Prolinemia Type II; Sarcosinemia |
| PharmGKB | PA164778930 |
| ChEMBL | CHEMBL283800 |
