| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44041843 | HTLV-1 | ENSG00000140443.15 | protein_coding | IGF1R | Yes | No | 3480 | C9J5X1 P08069 |
| TVIS44047281 | HTLV-1 | ENSG00000140443.15 | protein_coding | IGF1R | Yes | No | 3480 | C9J5X1 P08069 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | IGF1R |
|---|---|
| DrugBank ID | DB00030 |
| Drug Name | Insulin human |
| Target ID | BE0000858 |
| UniProt ID | P08069 |
| Regulation Type | activator |
| PubMed IDs | 19145584; 21219237; 22420005; 31771180; 25905175 |
| Citations | Weinstein D, Simon M, Yehezkel E, Laron Z, Werner H: Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells. Diabetes Metab Res Rev. 2009 Jan;25(1):41-9. doi: 10.1002/dmrr.912.@@Werner H, Weinstein D, Yehezkel E, Laron Z: Controversies in the use of insulin analogues. Expert Opin Biol Ther. 2011 Feb;11(2):199-209. doi: 10.1517/14712598.2011.540233.@@Varewijck AJ, Janssen JA: Insulin and its analogues and their affinities for the IGF1 receptor. Endocr Relat Cancer. 2012 Sep 5;19(5):F63-75. doi: 10.1530/ERC-12-0026. Print 2012 Oct.@@Sarfstein R, Nagaraj K, LeRoith D, Werner H: Differential Effects of Insulin and IGF1 Receptors on ERK and AKT Subcellular Distribution in Breast Cancer Cells. Cells. 2019 Nov 23;8(12). pii: cells8121499. doi: 10.3390/cells8121499.@@Donner T, Sarkar S: Insulin - Pharmacology, Therapeutic Regimens, and Principles of Intensive Insulin Therapy . |
| Groups | Approved; Investigational |
| Direct Classification | Peptides |
| SMILES | |
| Pathways | |
| PharmGKB | PA164744571 |
| ChEMBL |
