| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44027690 | HTLV-1 | ENSG00000171105.14 | protein_coding | INSR | Yes | No | 3643 | P06213 |
| TVIS44033127 | HTLV-1 | ENSG00000171105.14 | protein_coding | INSR | Yes | No | 3643 | P06213 |
| TVIS44003490 | HTLV-1 | ENSG00000171105.14 | protein_coding | INSR | Yes | No | 3643 | P06213 |
| TVIS44003251 | HTLV-1 | ENSG00000171105.14 | protein_coding | INSR | Yes | No | 3643 | P06213 |
| TVIS44047888 | HTLV-1 | ENSG00000171105.14 | protein_coding | INSR | Yes | No | 3643 | P06213 |
| TVIS44035075 | HTLV-1 | ENSG00000171105.14 | protein_coding | INSR | Yes | No | 3643 | P06213 |
| TVIS44047887 | HTLV-1 | ENSG00000171105.14 | protein_coding | INSR | Yes | No | 3643 | P06213 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | INSR |
|---|---|
| DrugBank ID | DB00030 |
| Drug Name | Insulin human |
| Target ID | BE0000033 |
| UniProt ID | P06213 |
| Regulation Type | agonist |
| PubMed IDs | 12970169; 12038982; 17722952; 19683471; 20230616; 11752352; 27512793 |
| Citations | Desbuquois B, Chauvet G, Kouach M, Authier F: Cell itinerary and metabolic fate of proinsulin in rat liver: in vivo and in vitro studies. Endocrinology. 2003 Dec;144(12):5308-21. Epub 2003 Sep 11.@@Chen LM, Yang XW, Tang JG: Acidic residues on the N-terminus of proinsulin C-Peptide are important for the folding of insulin precursor. J Biochem. 2002 Jun;131(6):855-9.@@Bell DS: Insulin therapy in diabetes mellitus: how can the currently available injectable insulins be most prudently and efficaciously utilised? Drugs. 2007;67(13):1813-27.@@Tanti JF, Jager J: Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation. Curr Opin Pharmacol. 2009 Dec;9(6):753-62. doi: 10.1016/j.coph.2009.07.004. Epub 2009 Aug 13.@@Chiu SL, Cline HT: Insulin receptor signaling in the development of neuronal structure and function. Neural Dev. 2010 Mar 15;5:7. doi: 10.1186/1749-8104-5-7.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@De Meyts P: The Insulin Receptor and Its Signal Transduction Network . |
| Groups | Approved; Investigational |
| Direct Classification | Peptides |
| SMILES | |
| Pathways | |
| PharmGKB | PA164744571 |
| ChEMBL |
