| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44027690 | HTLV-1 | ENSG00000171105.14 | protein_coding | INSR | Yes | No | 3643 | P06213 |
| TVIS44033127 | HTLV-1 | ENSG00000171105.14 | protein_coding | INSR | Yes | No | 3643 | P06213 |
| TVIS44003490 | HTLV-1 | ENSG00000171105.14 | protein_coding | INSR | Yes | No | 3643 | P06213 |
| TVIS44003251 | HTLV-1 | ENSG00000171105.14 | protein_coding | INSR | Yes | No | 3643 | P06213 |
| TVIS44047888 | HTLV-1 | ENSG00000171105.14 | protein_coding | INSR | Yes | No | 3643 | P06213 |
| TVIS44035075 | HTLV-1 | ENSG00000171105.14 | protein_coding | INSR | Yes | No | 3643 | P06213 |
| TVIS44047887 | HTLV-1 | ENSG00000171105.14 | protein_coding | INSR | Yes | No | 3643 | P06213 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | INSR |
|---|---|
| DrugBank ID | DB06075 |
| Drug Name | Linsitinib |
| Target ID | BE0000033 |
| UniProt ID | P06213 |
| Regulation Type | inhibitor |
| PubMed IDs | 21425998; 25208878; 17671083 |
| Citations | Mulvihill MJ, Cooke A, Rosenfeld-Franklin M, Buck E, Foreman K, Landfair D, O'Connor M, Pirritt C, Sun Y, Yao Y, Arnold LD, Gibson NW, Ji QS: Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor. Future Med Chem. 2009 Sep;1(6):1153-71. doi: 10.4155/fmc.09.89.@@Jones RL, Kim ES, Nava-Parada P, Alam S, Johnson FM, Stephens AW, Simantov R, Poondru S, Gedrich R, Lippman SM, Kaye SB, Carden CP: Phase I study of intermittent oral dosing of the insulin-like growth factor-1 and insulin receptors inhibitor OSI-906 in patients with advanced solid tumors. Clin Cancer Res. 2015 Feb 15;21(4):693-700. doi: 10.1158/1078-0432.CCR-14-0265. Epub 2014 Sep 10.@@Ji QS, Mulvihill MJ, Rosenfeld-Franklin M, Cooke A, Feng L, Mak G, O'Connor M, Yao Y, Pirritt C, Buck E, Eyzaguirre A, Arnold LD, Gibson NW, Pachter JA: A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo. Mol Cancer Ther. 2007 Aug;6(8):2158-67. doi: 10.1158/1535-7163.MCT-07-0070. Epub 2007 Aug 1. |
| Groups | Investigational |
| Direct Classification | |
| SMILES | C[C@@]1(O)C[C@@H](C1)C1=NC(=C2N1C=CN=C2N)C1=CC=C2C=CC(=NC2=C1)C1=CC=CC=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL1091644 |
