| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10011321 | HBV | ENSG00000196549.13 | protein_coding | MME | No | No | 4311 | P08473 |
| TVIS10011322 | HBV | ENSG00000196549.13 | protein_coding | MME | No | No | 4311 | P08473 |
| TVIS10032436 | HBV | ENSG00000196549.13 | protein_coding | MME | No | No | 4311 | P08473 |
| TVIS30058704 | HIV | ENSG00000196549.13 | protein_coding | MME | No | No | 4311 | P08473 |
| TVIS30058705 | HIV | ENSG00000196549.13 | protein_coding | MME | No | No | 4311 | P08473 |
| TVIS30058706 | HIV | ENSG00000196549.13 | protein_coding | MME | No | No | 4311 | P08473 |
| TVIS30058707 | HIV | ENSG00000196549.13 | protein_coding | MME | No | No | 4311 | P08473 |
| TVIS30058708 | HIV | ENSG00000196549.13 | protein_coding | MME | No | No | 4311 | P08473 |
| TVIS30058709 | HIV | ENSG00000196549.13 | protein_coding | MME | No | No | 4311 | P08473 |
| TVIS20003440 | HPV | ENSG00000196549.13 | protein_coding | MME | No | No | 4311 | P08473 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | MME |
|---|---|
| DrugBank ID | DB00616 |
| Drug Name | Candoxatril |
| Target ID | BE0000266 |
| UniProt ID | P08473 |
| Regulation Type | inhibitor |
| PubMed IDs | 1315825; 1386491; 16025254; 16449355; 7511759; 11752352 |
| Citations | O'Connell JE, Jardine AG, Davidson G, Connell JM: Candoxatril, an orally active neutral endopeptidase inhibitor, raises plasma atrial natriuretic factor and is natriuretic in essential hypertension. J Hypertens. 1992 Mar;10(3):271-7.@@Elsner D, Muntze A, Kromer EP, Riegger GA: Effectiveness of endopeptidase inhibition (candoxatril) in congestive heart failure. Am J Cardiol. 1992 Aug 15;70(4):494-8.@@Plamboeck A, Holst JJ, Carr RD, Deacon CF: Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both mediators of the degradation of glucagon-like peptide 1 in the anaesthetised pig. Diabetologia. 2005 Sep;48(9):1882-90. Epub 2005 Jul 16.@@Sansoe G, Aragno M, Mastrocola R, Cutrin JC, Silvano S, Mengozzi G, Smedile A, Rosina F, Danni O, Rizzetto M: Overexpression of kidney neutral endopeptidase (EC 3.4.24.11) and renal function in experimental cirrhosis. Am J Physiol Renal Physiol. 2006 Jun;290(6):F1337-43. Epub 2006 Jan 31.@@Hirata Y, Suzuki E, Hayakawa H, Matsuoka H, Sugimoto T, Kangawa K, Matsuo H: Mechanisms of the natriuretic effects of neutral endopeptidase inhibition in Dahl salt-sensitive and salt-resistant rats. J Cardiovasc Pharmacol. 1994 Feb;23(2):283-90.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Experimental |
| Direct Classification | Indanes |
| SMILES | COCCOC[C@H](CC1(CCCC1)C(=O)N[C@H]1CC[C@H](CC1)C(O)=O)C(=O)OC1=CC2=C(CCC2)C=C1 |
| Pathways | |
| PharmGKB | PA164764517 |
| ChEMBL | CHEMBL35084 |
