| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20017104 | HPV | ENSG00000134853.12 | protein_coding | PDGFRA | Yes | No | 5156 | P16234 |
| TVIS20058559 | HPV | ENSG00000134853.12 | protein_coding | PDGFRA | Yes | No | 5156 | P16234 |
| TVIS44048880 | HTLV-1 | ENSG00000134853.12 | protein_coding | PDGFRA | Yes | No | 5156 | P16234 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | PDGFRA |
|---|---|
| DrugBank ID | DB00102 |
| Drug Name | Becaplermin |
| Target ID | BE0000852 |
| UniProt ID | P16234 |
| Regulation Type | |
| PubMed IDs | 10070317; 7665222; 12632922; 1702511; 14506245 |
| Citations | Abdiu A, Walz TM, Nishikawa BK, Wingren S, Larsson SE, Wasteson A: Human malignant fibrous histiocytomas in vitro: growth characteristics and their association with expression of mRNA for platelet-derived growth factor, transforming growth factor-alpha and their receptors. Eur J Cancer. 1998 Dec;34(13):2094-100.@@Ebert M, Yokoyama M, Friess H, Kobrin MS, Buchler MW, Korc M: Induction of platelet-derived growth factor A and B chains and over-expression of their receptors in human pancreatic cancer. Int J Cancer. 1995 Sep 4;62(5):529-35.@@Miller-Kasprzak E, Niemir ZI, Czekalski S: [Structure and function of PDGF-R-alpha and its expression in normal kidney and kidney diseases]. Przegl Lek. 2002;59(10):826-31.@@Heidaran MA, Pierce JH, Lombardi D, Ruggiero M, Gutkind JS, Matsui T, Aaronson SA: Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways. Mol Cell Biol. 1991 Jan;11(1):134-42.@@Yu J, Liu XW, Kim HR: Platelet-derived growth factor (PDGF) receptor-alpha-activated c-Jun NH2-terminal kinase-1 is critical for PDGF-induced p21WAF1/CIP1 promoter activity independent of p53. J Biol Chem. 2003 Dec 5;278(49):49582-8. Epub 2003 Sep 23. |
| Groups | Approved; Investigational |
| Direct Classification | Peptides |
| SMILES | |
| Pathways | |
| PharmGKB | PA164749511 |
| ChEMBL | CHEMBL1201556 |
