| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30068866 | HIV | ENSG00000070501.12 | protein_coding | POLB | No | No | 5423 | P06746 |
| TVIS20040090 | HPV | ENSG00000070501.12 | protein_coding | POLB | No | No | 5423 | P06746 |
| TVIS20020491 | HPV | ENSG00000070501.12 | protein_coding | POLB | No | No | 5423 | P06746 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | POLB |
|---|---|
| DrugBank ID | DB00987 |
| Drug Name | Cytarabine |
| Target ID | BE0000113 |
| UniProt ID | P06746 |
| Regulation Type | inhibitor |
| PubMed IDs | 16866189; 15011952; 19372559 |
| Citations | Angeli JP, Ribeiro LR, Bellini MF, Mantovanil: Anti-clastogenic effect of beta-glucan extracted from barley towards chemically induced DNA damage in rodent cells. Hum Exp Toxicol. 2006 Jun;25(6):319-24.@@Miura S, Izuta S: DNA polymerases as targets of anticancer nucleosides. Curr Drug Targets. 2004 Feb;5(2):191-5.@@Krynetskaia NF, Phadke MS, Jadhav SH, Krynetskiy EY: Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage. Mol Cancer Ther. 2009 Apr;8(4):864-72. doi: 10.1158/1535-7163.MCT-08-0695. |
| Groups | Approved; Investigational |
| Direct Classification | Pyrimidine nucleosides |
| SMILES | NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O |
| Pathways | |
| PharmGKB | PA449177 |
| ChEMBL | CHEMBL803 |
