| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10039727 | HBV | ENSG00000151012.13 | protein_coding | SLC7A11 | No | No | 23657 | Q9UPY5 |
| TVIS30061189 | HIV | ENSG00000151012.13 | protein_coding | SLC7A11 | No | No | 23657 | Q9UPY5 |
| TVIS30061190 | HIV | ENSG00000151012.13 | protein_coding | SLC7A11 | No | No | 23657 | Q9UPY5 |
| TVIS30061191 | HIV | ENSG00000151012.13 | protein_coding | SLC7A11 | No | No | 23657 | Q9UPY5 |
| TVIS30061192 | HIV | ENSG00000151012.13 | protein_coding | SLC7A11 | No | No | 23657 | Q9UPY5 |
| TVIS20057922 | HPV | ENSG00000151012.13 | protein_coding | SLC7A11 | No | No | 23657 | Q9UPY5 |
| TVIS44030265 | HTLV-1 | ENSG00000151012.13 | protein_coding | SLC7A11 | No | No | 23657 | Q9UPY5 |
| TVIS44003704 | HTLV-1 | ENSG00000151012.13 | protein_coding | SLC7A11 | No | No | 23657 | Q9UPY5 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SLC7A11 |
|---|---|
| DrugBank ID | DB00138 |
| Drug Name | Cystine |
| Target ID | BE0000030 |
| UniProt ID | Q9UPY5 |
| Regulation Type | |
| PubMed IDs | 11867597; 12065721; 12498985; 16014042; 12898700 |
| Citations | Tomi M, Hosoya K, Takanaga H, Ohtsuki S, Terasaki T: Induction of xCT gene expression and L-cystine transport activity by diethyl maleate at the inner blood-retinal barrier. Invest Ophthalmol Vis Sci. 2002 Mar;43(3):774-9.@@Hosoya K, Tomi M, Ohtsuki S, Takanaga H, Saeki S, Kanai Y, Endou H, Naito M, Tsuruo T, Terasaki T: Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment. J Pharmacol Exp Ther. 2002 Jul;302(1):225-31.@@Ruiz E, Siow RC, Bartlett SR, Jenner AM, Sato H, Bannai S, Mann GE: Vitamin C inhibits diethylmaleate-induced L-cystine transport in human vascular smooth muscle cells. Free Radic Biol Med. 2003 Jan 1;34(1):103-10.@@Bridges CC, Zalups RK: Cystine and glutamate transport in renal epithelial cells transfected with human system x(-) (c). Kidney Int. 2005 Aug;68(2):653-64.@@Tomi M, Funaki T, Abukawa H, Katayama K, Kondo T, Ohtsuki S, Ueda M, Obinata M, Terasaki T, Hosoya K: Expression and regulation of L-cystine transporter, system xc-, in the newly developed rat retinal Muller cell line (TR-MUL). Glia. 2003 Sep;43(3):208-17. |
| Groups | Approved; Nutraceutical |
| Direct Classification | L-cysteine-S-conjugates |
| SMILES | N[C@@H](CSSC[C@H](N)C(O)=O)C(O)=O |
| Pathways | |
| PharmGKB | PA449176 |
| ChEMBL | CHEMBL590540 |
