| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10039727 | HBV | ENSG00000151012.13 | protein_coding | SLC7A11 | No | No | 23657 | Q9UPY5 |
| TVIS30061189 | HIV | ENSG00000151012.13 | protein_coding | SLC7A11 | No | No | 23657 | Q9UPY5 |
| TVIS30061190 | HIV | ENSG00000151012.13 | protein_coding | SLC7A11 | No | No | 23657 | Q9UPY5 |
| TVIS30061191 | HIV | ENSG00000151012.13 | protein_coding | SLC7A11 | No | No | 23657 | Q9UPY5 |
| TVIS30061192 | HIV | ENSG00000151012.13 | protein_coding | SLC7A11 | No | No | 23657 | Q9UPY5 |
| TVIS20057922 | HPV | ENSG00000151012.13 | protein_coding | SLC7A11 | No | No | 23657 | Q9UPY5 |
| TVIS44030265 | HTLV-1 | ENSG00000151012.13 | protein_coding | SLC7A11 | No | No | 23657 | Q9UPY5 |
| TVIS44003704 | HTLV-1 | ENSG00000151012.13 | protein_coding | SLC7A11 | No | No | 23657 | Q9UPY5 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | SLC7A11 |
|---|---|
| DrugBank ID | DB00740 |
| Drug Name | Riluzole |
| Target ID | BE0000030 |
| UniProt ID | Q9UPY5 |
| Regulation Type | inducer |
| PubMed IDs | 8813989; 10899284; 12629173; 20226190; 20059984 |
| Citations | Wokke J: Riluzole. Lancet. 1996 Sep 21;348(9030):795-9.@@Azbill RD, Mu X, Springer JE: Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes. Brain Res. 2000 Jul 21;871(2):175-80.@@Dunlop J, Beal McIlvain H, She Y, Howland DS: Impaired spinal cord glutamate transport capacity and reduced sensitivity to riluzole in a transgenic superoxide dismutase mutant rat model of amyotrophic lateral sclerosis. J Neurosci. 2003 Mar 1;23(5):1688-96.@@Gosselin RD, O'Connor RM, Tramullas M, Julio-Pieper M, Dinan TG, Cryan JF: Riluzole normalizes early-life stress-induced visceral hypersensitivity in rats: role of spinal glutamate reuptake mechanisms. Gastroenterology. 2010 Jun;138(7):2418-25. doi: 10.1053/j.gastro.2010.03.003. Epub 2010 Mar 10.@@Hayashida K, Parker RA, Eisenach JC: Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats. Brain Res. 2010 Mar 4;1317:80-6. doi: 10.1016/j.brainres.2009.12.086. Epub 2010 Jan 6. |
| Groups | Approved; Investigational |
| Direct Classification | Benzothiazoles |
| SMILES | NC1=NC2=C(S1)C=C(OC(F)(F)F)C=C2 |
| Pathways | |
| PharmGKB | PA451251 |
| ChEMBL | CHEMBL744 |
