| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30082168 | HIV | ENSG00000184012.14 | protein_coding | TMPRSS2 | No | No | 7113 | O15393 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TMPRSS2 |
|---|---|
| DrugBank ID | DB09019 |
| Drug Name | Bromhexine |
| Target ID | BE0009920 |
| UniProt ID | O15393 |
| Regulation Type | |
| PubMed IDs | 32360584; 32334052; 32458206 |
| Citations | Habtemariam S, Nabavi SF, Ghavami S, Cismaru CA, Berindan-Neagoe I, Nabavi SM: Possible use of the mucolytic drug, bromhexine hydrochloride, as a prophylactic agent against SARS-CoV-2 infection based on its action on the Transmembrane Serine Protease 2. Pharmacol Res. 2020 Jul;157:104853. doi: 10.1016/j.phrs.2020.104853. Epub 2020 Apr 30.@@Maggio R, Corsini GU: Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection. Pharmacol Res. 2020 Jul;157:104837. doi: 10.1016/j.phrs.2020.104837. Epub 2020 Apr 22.@@Depfenhart M, de Villiers D, Lemperle G, Meyer M, Di Somma S: Potential new treatment strategies for COVID-19: is there a role for bromhexine as add-on therapy? Intern Emerg Med. 2020 Aug;15(5):801-812. doi: 10.1007/s11739-020-02383-3. Epub 2020 May 26. |
| Groups | Approved |
| Direct Classification | Phenylmethylamines |
| SMILES | CN(CC1=CC(Br)=CC(Br)=C1N)C1CCCCC1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL253376 |
