| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20012158 | HPV | ENSG00000127824.15 | protein_coding | TUBA4A | No | No | 7277 | P68366 |
| TVIS20054211 | HPV | ENSG00000127824.15 | protein_coding | TUBA4A | No | No | 7277 | P68366 |
| TVIS20065366 | HPV | ENSG00000127824.15 | protein_coding | TUBA4A | No | No | 7277 | P68366 |
| TVIS44029086 | HTLV-1 | ENSG00000127824.15 | protein_coding | TUBA4A | No | No | 7277 | P68366 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TUBA4A |
|---|---|
| DrugBank ID | DB00541 |
| Drug Name | Vincristine |
| Target ID | BE0001391 |
| UniProt ID | P68366 |
| Regulation Type | inhibitor |
| PubMed IDs | 20691709; 20442307; 11168494 |
| Citations | Yasui M, Koyama N, Koizumi T, Senda-Murata K, Takashima Y, Hayashi M, Sugimoto K, Honma M: Live cell imaging of micronucleus formation and development. Mutat Res. 2010 Oct 13;692(1-2):12-8. doi: 10.1016/j.mrfmmm.2010.07.009. Epub 2010 Aug 5.@@Gan PP, McCarroll JA, Po'uha ST, Kamath K, Jordan MA, Kavallaris M: Microtubule dynamics, mitotic arrest, and apoptosis: drug-induced differential effects of betaIII-tubulin. Mol Cancer Ther. 2010 May;9(5):1339-48. doi: 10.1158/1535-7163.MCT-09-0679. Epub 2010 May 4.@@Vilpo JA, Koski T, Vilpo LM: Selective toxicity of vincristine against chronic lymphocytic leukemia cells in vitro. Eur J Haematol. 2000 Dec;65(6):370-8. |
| Groups | Approved; Investigational |
| Direct Classification | Vinca alkaloids |
| SMILES | [H][C@@]12N3CC[C@@]11C4=C(C=C(OC)C(=C4)[C@]4(C[C@H]5C[N@](C[C@](O)(CC)C5)CCC5=C4NC4=CC=CC=C54)C(=O)OC)N(C=O)[C@@]1([H])[C@](O)([C@H](OC(C)=O)[C@]2(CC)C=CC3)C(=O)OC |
| Pathways | Vincristine Action Pathway |
| PharmGKB | PA451879 |
| ChEMBL | CHEMBL499458 |
