| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20012158 | HPV | ENSG00000127824.15 | protein_coding | TUBA4A | No | No | 7277 | P68366 |
| TVIS20054211 | HPV | ENSG00000127824.15 | protein_coding | TUBA4A | No | No | 7277 | P68366 |
| TVIS20065366 | HPV | ENSG00000127824.15 | protein_coding | TUBA4A | No | No | 7277 | P68366 |
| TVIS44029086 | HTLV-1 | ENSG00000127824.15 | protein_coding | TUBA4A | No | No | 7277 | P68366 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TUBA4A |
|---|---|
| DrugBank ID | DB01179 |
| Drug Name | Podofilox |
| Target ID | BE0001391 |
| UniProt ID | P68366 |
| Regulation Type | inhibitor |
| PubMed IDs | 20979080; 20814887; 20810285; 20657644; 19286405; 1411635 |
| Citations | Labruere R, Gautier B, Testud M, Seguin J, Lenoir C, Desbene-Finck S, Helissey P, Garbay C, Chabot GG, Vidal M, Giorgi-Renault S: Design, synthesis, and biological evaluation of the first podophyllotoxin analogues as potential vascular-disrupting agents. ChemMedChem. 2010 Dec 3;5(12):2016-25. doi: 10.1002/cmdc.201000305.@@Li CM, Lu Y, Ahn S, Narayanan R, Miller DD, Dalton JT: Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin. J Mass Spectrom. 2010 Oct;45(10):1160-6. doi: 10.1002/jms.1804.@@Kim ND, Park ES, Kim YH, Moon SK, Lee SS, Ahn SK, Yu DY, No KT, Kim KH: Structure-based virtual screening of novel tubulin inhibitors and their characterization as anti-mitotic agents. Bioorg Med Chem. 2010 Oct 1;18(19):7092-100. doi: 10.1016/j.bmc.2010.07.072. Epub 2010 Aug 6.@@Screpanti E, Santaguida S, Nguyen T, Silvestri R, Gussio R, Musacchio A, Hamel E, De Wulf P: A screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compounds. PLoS One. 2010 Jul 15;5(7):e11603. doi: 10.1371/journal.pone.0011603.@@Alam MA, Naik PK: Applying linear interaction energy method for binding affinity calculations of podophyllotoxin analogues with tubulin using continuum solvent model and prediction of cytotoxic activity. J Mol Graph Model. 2009 Jun-Jul;27(8):930-43. doi: 10.1016/j.jmgm.2009.02.003. Epub 2009 Feb 20.@@Clark PI: Clinical pharmacology and schedule dependency of the podophyllotoxin derivatives. Semin Oncol. 1992 Apr;19(2 Suppl 6):20-7. |
| Groups | Approved |
| Direct Classification | Podophyllotoxins |
| SMILES | [H][C@]12COC(=O)[C@]1([H])[C@H](C1=CC(OC)=C(OC)C(OC)=C1)C1=CC3=C(OCO3)C=C1[C@@H]2O |
| Pathways | |
| PharmGKB | PA450993 |
| ChEMBL | CHEMBL61 |
