| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10016007 | HBV | ENSG00000164344.17 | protein_coding | KLKB1 | No | No | 3818 | E9PBC5 P03952 |
| TVIS10029862 | HBV | ENSG00000164344.17 | protein_coding | KLKB1 | No | No | 3818 | E9PBC5 P03952 |
| TVIS30077936 | HIV | ENSG00000164344.17 | protein_coding | KLKB1 | No | No | 3818 | E9PBC5 P03952 |
| TVIS20026118 | HPV | ENSG00000164344.17 | protein_coding | KLKB1 | No | No | 3818 | E9PBC5 P03952 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | KLKB1 |
|---|---|
| DrugBank ID | DB15982 |
| Drug Name | Berotralstat |
| Target ID | BE0002440 |
| UniProt ID | P03952 |
| Regulation Type | inhibitor |
| PubMed IDs | 31635497; 30044938 |
| Citations | Hwang JR, Hwang G, Johri A, Craig T: Oral plasma kallikrein inhibitor BCX7353 for treatment of hereditary angioedema. Immunotherapy. 2019 Dec;11(17):1439-1444. doi: 10.2217/imt-2019-0128. Epub 2019 Oct 22.@@Aygoren-Pursun E, Bygum A, Grivcheva-Panovska V, Magerl M, Graff J, Steiner UC, Fain O, Huissoon A, Kinaciyan T, Farkas H, Lleonart R, Longhurst HJ, Rae W, Triggiani M, Aberer W, Cancian M, Zanichelli A, Smith WB, Baeza ML, Du-Thanh A, Gompels M, Gonzalez-Quevedo T, Greve J, Guilarte M, Katelaris C, Dobo S, Cornpropst M, Clemons D, Fang L, Collis P, Sheridan W, Maurer M, Cicardi M: Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema. N Engl J Med. 2018 Jul 26;379(4):352-362. doi: 10.1056/NEJMoa1716995. |
| Groups | Approved |
| Direct Classification | |
| SMILES | NCC1=CC(=CC=C1)N1N=C(C=C1C(=O)NC1=CC(=CC=C1F)[C@H](NCC1CC1)C1=CC=CC(=C1)C#N)C(F)(F)F |
| Pathways | |
| PharmGKB | |
| ChEMBL |
