| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10016007 | HBV | ENSG00000164344.17 | protein_coding | KLKB1 | No | No | 3818 | E9PBC5 P03952 |
| TVIS10029862 | HBV | ENSG00000164344.17 | protein_coding | KLKB1 | No | No | 3818 | E9PBC5 P03952 |
| TVIS30077936 | HIV | ENSG00000164344.17 | protein_coding | KLKB1 | No | No | 3818 | E9PBC5 P03952 |
| TVIS20026118 | HPV | ENSG00000164344.17 | protein_coding | KLKB1 | No | No | 3818 | E9PBC5 P03952 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | KLKB1 |
|---|---|
| DrugBank ID | DB14597 |
| Drug Name | Lanadelumab |
| Target ID | BE0002440 |
| UniProt ID | P03952 |
| Regulation Type | inhibitor |
| PubMed IDs | 27960628; 29043014; 28225674; 31657963 |
| Citations | Reichert JM: Antibodies to watch in 2017. MAbs. 2017 Feb/Mar;9(2):167-181. doi: 10.1080/19420862.2016.1269580. Epub 2016 Dec 14.@@Riedl MA, Bernstein JA, Craig T, Banerji A, Magerl M, Cicardi M, Longhurst HJ, Shennak MM, Yang WH, Schranz J, Baptista J, Busse PJ: An open-label study to evaluate the long-term safety and efficacy of lanadelumab for prevention of attacks in hereditary angioedema: design of the HELP study extension. Clin Transl Allergy. 2017 Oct 6;7:36. doi: 10.1186/s13601-017-0172-9. eCollection 2017.@@Banerji A, Busse P, Shennak M, Lumry W, Davis-Lorton M, Wedner HJ, Jacobs J, Baker J, Bernstein JA, Lockey R, Li HH, Craig T, Cicardi M, Riedl M, Al-Ghazawi A, Soo C, Iarrobino R, Sexton DJ, TenHoor C, Kenniston JA, Faucette R, Still JG, Kushner H, Mensah R, Stevens C, Biedenkapp JC, Chyung Y, Adelman B: Inhibiting Plasma Kallikrein for Hereditary Angioedema Prophylaxis. N Engl J Med. 2017 Feb 23;376(8):717-728. doi: 10.1056/NEJMoa1605767.@@Wu MA: Lanadelumab for the treatment of hereditary angioedema. Expert Opin Biol Ther. 2019 Dec;19(12):1233-1245. doi: 10.1080/14712598.2019.1685490. Epub 2019 Nov 4. |
| Groups | Approved; Investigational |
| Direct Classification | Peptides |
| SMILES | |
| Pathways | |
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| ChEMBL |
