| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10011228 | HBV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
| TVIS30005072 | HIV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
| TVIS30005073 | HIV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
| TVIS30001457 | HIV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
| TVIS30011160 | HIV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
| TVIS30014456 | HIV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
| TVIS30011161 | HIV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
| TVIS30005074 | HIV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
| TVIS30001458 | HIV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
| TVIS30011162 | HIV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PIK3CD |
|---|---|
| DrugBank ID | DB16217 |
| Drug Name | Leniolisib |
| Target ID | BE0002406 |
| UniProt ID | O00329 |
| Regulation Type | inhibitor |
| PubMed IDs | 28972011; 28947947 |
| Citations | Rao VK, Webster S, Dalm VASH, Sediva A, van Hagen PM, Holland S, Rosenzweig SD, Christ AD, Sloth B, Cabanski M, Joshi AD, de Buck S, Doucet J, Guerini D, Kalis C, Pylvaenaeinen I, Soldermann N, Kashyap A, Uzel G, Lenardo MJ, Patel DD, Lucas CL, Burkhart C: Effective "activated PI3Kdelta syndrome"-targeted therapy with the PI3Kdelta inhibitor leniolisib. Blood. 2017 Nov 23;130(21):2307-2316. doi: 10.1182/blood-2017-08-801191. Epub 2017 Sep 29.@@Hoegenauer K, Soldermann N, Zecri F, Strang RS, Graveleau N, Wolf RM, Cooke NG, Smith AB, Hollingworth GJ, Blanz J, Gutmann S, Rummel G, Littlewood-Evans A, Burkhart C: Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors. ACS Med Chem Lett. 2017 Aug 25;8(9):975-980. doi: 10.1021/acsmedchemlett.7b00293. eCollection 2017 Sep 14. |
| Groups | Approved; Investigational |
| Direct Classification | |
| SMILES | CCC(=O)N1CC[C@@H](C1)NC1=C2CN(CCC2=NC=N1)C1=CN=C(OC)C(=C1)C(F)(F)F |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL3643413 |
