| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30059931 | HIV | ENSG00000151834.16 | protein_coding | GABRA2 | No | No | 2555 | E9PBQ7 P47869 |
| TVIS30059932 | HIV | ENSG00000151834.16 | protein_coding | GABRA2 | No | No | 2555 | E9PBQ7 P47869 |
| TVIS30059933 | HIV | ENSG00000151834.16 | protein_coding | GABRA2 | No | No | 2555 | E9PBQ7 P47869 |
| TVIS30059934 | HIV | ENSG00000151834.16 | protein_coding | GABRA2 | No | No | 2555 | E9PBQ7 P47869 |
| TVIS20058474 | HPV | ENSG00000151834.16 | protein_coding | GABRA2 | No | No | 2555 | E9PBQ7 P47869 |
| TVIS20037924 | HPV | ENSG00000151834.16 | protein_coding | GABRA2 | No | No | 2555 | E9PBQ7 P47869 |
| TVIS20067984 | HPV | ENSG00000151834.16 | protein_coding | GABRA2 | No | No | 2555 | E9PBQ7 P47869 |
| TVIS44019356 | HTLV-1 | ENSG00000151834.16 | protein_coding | GABRA2 | No | No | 2555 | E9PBQ7 P47869 |
| TVIS44006829 | HTLV-1 | ENSG00000151834.16 | protein_coding | GABRA2 | No | No | 2555 | E9PBQ7 P47869 |
| TVIS44028343 | HTLV-1 | ENSG00000151834.16 | protein_coding | GABRA2 | No | No | 2555 | E9PBQ7 P47869 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | GABRA2 |
|---|---|
| DrugBank ID | DB01198 |
| Drug Name | Zopiclone |
| Target ID | BE0000381 |
| UniProt ID | P47869 |
| Regulation Type | potentiator |
| PubMed IDs | 19942638; 18973287; 20303942 |
| Citations | Nutt DJ, Stahl SM: Searching for perfect sleep: the continuing evolution of GABAA receptor modulators as hypnotics. J Psychopharmacol. 2010 Nov;24(11):1601-12. doi: 10.1177/0269881109106927. Epub 2009 Nov 26.@@Hanson SM, Morlock EV, Satyshur KA, Czajkowski C: Structural requirements for eszopiclone and zolpidem binding to the gamma-aminobutyric acid type-A (GABAA) receptor are different. J Med Chem. 2008 Nov 27;51(22):7243-52. doi: 10.1021/jm800889m.@@Ramerstorfer J, Furtmuller R, Vogel E, Huck S, Sieghart W: The point mutation gamma 2F77I changes the potency and efficacy of benzodiazepine site ligands in different GABAA receptor subtypes. Eur J Pharmacol. 2010 Jun 25;636(1-3):18-27. doi: 10.1016/j.ejphar.2010.03.015. Epub 2010 Mar 19. |
| Groups | Approved |
| Direct Classification | Cyclopyrrolones |
| SMILES | CN1CCN(CC1)C(=O)OC1N(C(=O)C2=NC=CN=C12)C1=NC=C(Cl)C=C1 |
| Pathways | |
| PharmGKB | PA10236 |
| ChEMBL | CHEMBL135400 |
