| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30055939 | HIV | ENSG00000186951.17 | protein_coding | PPARA | No | No | 5465 | Q07869 |
| TVIS30055940 | HIV | ENSG00000186951.17 | protein_coding | PPARA | No | No | 5465 | Q07869 |
| TVIS30055941 | HIV | ENSG00000186951.17 | protein_coding | PPARA | No | No | 5465 | Q07869 |
| TVIS20040704 | HPV | ENSG00000186951.17 | protein_coding | PPARA | No | No | 5465 | Q07869 |
| TVIS44043072 | HTLV-1 | ENSG00000186951.17 | protein_coding | PPARA | No | No | 5465 | Q07869 |
| TVIS44048213 | HTLV-1 | ENSG00000186951.17 | protein_coding | PPARA | No | No | 5465 | Q07869 |
| TVIS44048233 | HTLV-1 | ENSG00000186951.17 | protein_coding | PPARA | No | No | 5465 | Q07869 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PPARA |
|---|---|
| DrugBank ID | DB01393 |
| Drug Name | Bezafibrate |
| Target ID | BE0000071 |
| UniProt ID | Q07869 |
| Regulation Type | agonist |
| PubMed IDs | 10909982; 10933891; 11172467; 11422732; 11519881; 18629356; 16511610; 11752352 |
| Citations | Pedraza N, Solanes G, Carmona MC, Iglesias R, Vinas O, Mampel T, Vazquez M, Giralt M, Villarroya F: Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene. Diabetes. 2000 Jul;49(7):1224-30.@@Cabrero A, Alegret M, Sanchez R, Adzet T, Laguna JC, Vazquez M: Peroxisome proliferator-activated receptor alpha (PPARalpha) activators, bezafibrate and Wy-14,643, increase uncoupling protein-3 mRNA levels without modifying the mitochondrial membrane potential in primary culture of rat preadipocytes. Arch Biochem Biophys. 2000 Aug 15;380(2):353-9.@@Inoue I, Goto S, Matsunaga T, Nakajima T, Awata T, Hokari S, Komoda T, Katayama S: The ligands/activators for peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma increase Cu2+,Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells. Metabolism. 2001 Jan;50(1):3-11.@@Guan Y, Breyer MD: Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease. Kidney Int. 2001 Jul;60(1):14-30.@@Bonilla S, Redonnet A, Noel-Suberville C, Groubet R, Pallet V, Higueret P: Effect of a pharmacological activation of PPAR on the expression of RAR and TR in rat liver. J Physiol Biochem. 2001 Mar;57(1):1-8.@@Goldenberg I, Benderly M, Goldbourt U: Update on the use of fibrates: focus on bezafibrate. Vasc Health Risk Manag. 2008;4(1):131-41.@@Fruchart JC, Duriez P: Mode of action of fibrates in the regulation of triglyceride and HDL-cholesterol metabolism. Drugs Today (Barc). 2006 Jan;42(1):39-64.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Investigational |
| Direct Classification | Phenoxyacetic acid derivatives |
| SMILES | CC(C)(OC1=CC=C(CCNC(=O)C2=CC=C(Cl)C=C2)C=C1)C(O)=O |
| Pathways | |
| PharmGKB | PA162364313 |
| ChEMBL | CHEMBL264374 |
