| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30062310 | HIV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS30062311 | HIV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS30062312 | HIV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS30062313 | HIV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS30062314 | HIV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS20001830 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS20001312 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS20001313 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS20006556 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
| TVIS20008253 | HPV | ENSG00000113448.21 | protein_coding | PDE4D | No | No | 5144 | A0A140VJR0 Q08499 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PDE4D |
|---|---|
| DrugBank ID | DB05219 |
| Drug Name | Crisaborole |
| Target ID | BE0001287 |
| UniProt ID | Q08499 |
| Regulation Type | inhibitor |
| PubMed IDs | 22841723 |
| Citations | Freund YR, Akama T, Alley MR, Antunes J, Dong C, Jarnagin K, Kimura R, Nieman JA, Maples KR, Plattner JJ, Rock F, Sharma R, Singh R, Sanders V, Zhou Y: Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center. FEBS Lett. 2012 Sep 21;586(19):3410-4. doi: 10.1016/j.febslet.2012.07.058. Epub 2012 Jul 25. |
| Groups | Approved; Investigational |
| Direct Classification | Diarylethers |
| SMILES | OB1OCC2=C1C=CC(OC1=CC=C(C=C1)C#N)=C2 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL484785 |
