Target Gene Table ▼
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS10039136HBVENSG00000147246.10protein_codingHTR2CNoNo3358P28335
TVIS30073496HIVENSG00000147246.10protein_codingHTR2CNoNo3358P28335
TVIS30073497HIVENSG00000147246.10protein_codingHTR2CNoNo3358P28335
TVIS20011278HPVENSG00000147246.10protein_codingHTR2CNoNo3358P28335
TVIS20029983HPVENSG00000147246.10protein_codingHTR2CNoNo3358P28335
TVIS20029984HPVENSG00000147246.10protein_codingHTR2CNoNo3358P28335
TVIS20029985HPVENSG00000147246.10protein_codingHTR2CNoNo3358P28335
TVIS20029986HPVENSG00000147246.10protein_codingHTR2CNoNo3358P28335
TVIS20029987HPVENSG00000147246.10protein_codingHTR2CNoNo3358P28335
TVIS20064469HPVENSG00000147246.10protein_codingHTR2CNoNo3358P28335
TCGA Plot Options ▼
Drug Information ▼
GeneHTR2C
DrugBank IDDB00574
Drug NameFenfluramine
Target IDBE0000533
UniProt IDP28335
Regulation Typeagonist
PubMed IDs10617681; 12708517; 15869562; 16249524; 16973729; 32169824; 10498829; 29805740; 31116409; 26822114; 28428755
CitationsFitzgerald LW, Burn TC, Brown BS, Patterson JP, Corjay MH, Valentine PA, Sun JH, Link JR, Abbaszade I, Hollis JM, Largent BL, Hartig PR, Hollis GF, Meunier PC, Robichaud AJ, Robertson DW: Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine. Mol Pharmacol. 2000 Jan;57(1):75-81.@@McCreary AC, Filip M, Cunningham KA: Discriminative stimulus properties of (+/-)-fenfluramine: the role of 5-HT2 receptor subtypes. Behav Neurosci. 2003 Apr;117(2):212-21.@@Schuhler S, Clark A, Joseph W, Patel A, Lehnen K, Stratford E, Horan TL, Fone KC, Ebling FJ: Involvement of 5-HT receptors in the regulation of food intake in Siberian hamsters. J Neuroendocrinol. 2005 May;17(5):276-85.@@Miller KJ: Serotonin 5-ht2c receptor agonists: potential for the treatment of obesity. Mol Interv. 2005 Oct;5(5):282-91.@@Nonogaki K, Nozue K, Oka Y: Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice. Endocrinology. 2006 Dec;147(12):5893-900. Epub 2006 Sep 14.@@Martin P, de Witte PAM, Maurice T, Gammaitoni A, Farfel G, Galer B: Fenfluramine acts as a positive modulator of sigma-1 receptors. Epilepsy Behav. 2020 Apr;105:106989. doi: 10.1016/j.yebeh.2020.106989. Epub 2020 Mar 10.@@Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, Adams DR, Sheardown MJ: Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br J Pharmacol. 1999 Sep;128(1):13-20.@@Rodriguez-Munoz M, Sanchez-Blazquez P, Garzon J: Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors. Oncotarget. 2018 May 4;9(34):23373-23389. doi: 10.18632/oncotarget.25169. eCollection 2018 May 4.@@Schoonjans AS, Ceulemans B: An Old Drug for a New Indication: Repurposing Fenfluramine From an Anorexigen to an Antiepileptic Drug. Clin Pharmacol Ther. 2019 Nov;106(5):929-932. doi: 10.1002/cpt.1469. Epub 2019 May 22.@@Sourbron J, Schneider H, Kecskes A, Liu Y, Buening EM, Lagae L, Smolders I, de Witte P: Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model. ACS Chem Neurosci. 2016 May 18;7(5):588-98. doi: 10.1021/acschemneuro.5b00342. Epub 2016 Feb 17.@@Sourbron J, Smolders I, de Witte P, Lagae L: Pharmacological Analysis of the Anti-epileptic Mechanisms of Fenfluramine in scn1a Mutant Zebrafish. Front Pharmacol. 2017 Apr 6;8:191. doi: 10.3389/fphar.2017.00191. eCollection 2017.
GroupsApproved; Illicit; Investigational; Withdrawn
Direct ClassificationAmphetamines and derivatives
SMILESCCNC(C)CC1=CC=CC(=C1)C(F)(F)F
Pathways
PharmGKBPA449592
ChEMBLCHEMBL87493