| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10039136 | HBV | ENSG00000147246.10 | protein_coding | HTR2C | No | No | 3358 | P28335 |
| TVIS30073496 | HIV | ENSG00000147246.10 | protein_coding | HTR2C | No | No | 3358 | P28335 |
| TVIS30073497 | HIV | ENSG00000147246.10 | protein_coding | HTR2C | No | No | 3358 | P28335 |
| TVIS20011278 | HPV | ENSG00000147246.10 | protein_coding | HTR2C | No | No | 3358 | P28335 |
| TVIS20029983 | HPV | ENSG00000147246.10 | protein_coding | HTR2C | No | No | 3358 | P28335 |
| TVIS20029984 | HPV | ENSG00000147246.10 | protein_coding | HTR2C | No | No | 3358 | P28335 |
| TVIS20029985 | HPV | ENSG00000147246.10 | protein_coding | HTR2C | No | No | 3358 | P28335 |
| TVIS20029986 | HPV | ENSG00000147246.10 | protein_coding | HTR2C | No | No | 3358 | P28335 |
| TVIS20029987 | HPV | ENSG00000147246.10 | protein_coding | HTR2C | No | No | 3358 | P28335 |
| TVIS20064469 | HPV | ENSG00000147246.10 | protein_coding | HTR2C | No | No | 3358 | P28335 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | HTR2C |
|---|---|
| DrugBank ID | DB00656 |
| Drug Name | Trazodone |
| Target ID | BE0000533 |
| UniProt ID | P28335 |
| Regulation Type | agonist |
| PubMed IDs | 7659770; 3039120; 10594316; 1365657; 15614572 |
| Citations | Fiorella D, Rabin RA, Winter JC: The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of m-chlorophenylpiperazine. Psychopharmacology (Berl). 1995 May;119(2):222-30.@@Conn PJ, Sanders-Bush E: Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors. J Pharmacol Exp Ther. 1987 Aug;242(2):552-7.@@Pazzagli M, Giovannini MG, Pepeu G: Trazodone increases extracellular serotonin levels in the frontal cortex of rats. Eur J Pharmacol. 1999 Nov 3;383(3):249-57. doi: 10.1016/s0014-2999(99)00644-5.@@Marek GJ, McDougle CJ, Price LH, Seiden LS: A comparison of trazodone and fluoxetine: implications for a serotonergic mechanism of antidepressant action. Psychopharmacology (Berl). 1992;109(1-2):2-11.@@Balsara JJ, Jadhav SA, Gaonkar RK, Gaikwad RV, Jadhav JH: Effects of the antidepressant trazodone, a 5-HT 2A/2C receptor antagonist, on dopamine-dependent behaviors in rats. Psychopharmacology (Berl). 2005 May;179(3):597-605. doi: 10.1007/s00213-004-2095-0. Epub 2004 Dec 22. |
| Groups | Approved; Investigational |
| Direct Classification | Phenylpiperazines |
| SMILES | ClC1=CC=CC(=C1)N1CCN(CCCN2N=C3C=CC=CN3C2=O)CC1 |
| Pathways | |
| PharmGKB | PA451744 |
| ChEMBL | CHEMBL621 |
