| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10006515 | HBV | ENSG00000023839.12 | protein_coding | ABCC2 | No | No | 1244 | Q92887 |
| TVIS10019341 | HBV | ENSG00000023839.12 | protein_coding | ABCC2 | No | No | 1244 | Q92887 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ABCC2 |
|---|---|
| DrugBank ID | DB01138 |
| Drug Name | Sulfinpyrazone |
| Target ID | BE0001069 |
| UniProt ID | Q92887 |
| Regulation Type | inhibitor |
| PubMed IDs | 10727523; 10917554; 11108662; 11500505; 11834888; 17229912 |
| Citations | Bakos E, Evers R, Sinko E, Varadi A, Borst P, Sarkadi B: Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57(4):760-8.@@Evers R, de Haas M, Sparidans R, Beijnen J, Wielinga PR, Lankelma J, Borst P: Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83.@@Morrow CS, Smitherman PK, Townsend AJ: Role of multidrug-resistance protein 2 in glutathione S-transferase P1-1-mediated resistance to 4-nitroquinoline 1-oxide toxicities in HepG2 cells. Mol Carcinog. 2000 Nov;29(3):170-8.@@Ito K, Oleschuk CJ, Westlake C, Vasa MZ, Deeley RG, Cole SP: Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. J Biol Chem. 2001 Oct 12;276(41):38108-14. Epub 2001 Aug 10.@@Flanagan SD, Cummins CL, Susanto M, Liu X, Takahashi LH, Benet LZ: Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2). Pharmacology. 2002;64(3):126-34.@@Hagos Y, Stein D, Ugele B, Burckhardt G, Bahn A: Human renal organic anion transporter 4 operates as an asymmetric urate transporter. J Am Soc Nephrol. 2007 Feb;18(2):430-9. Epub 2007 Jan 17. |
| Groups | Approved |
| Direct Classification | Phenyl sulfoxides |
| SMILES | O=C1C(CCS(=O)C2=CC=CC=C2)C(=O)N(N1C1=CC=CC=C1)C1=CC=CC=C1 |
| Pathways | |
| PharmGKB | PA451550 |
| ChEMBL | CHEMBL832 |
