| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30083001 | HIV | ENSG00000142208.19 | protein_coding | AKT1 | Yes | No | 207 | B0LPE5 P31749 |
| TVIS30037657 | HIV | ENSG00000142208.19 | protein_coding | AKT1 | Yes | No | 207 | B0LPE5 P31749 |
| TVIS30037658 | HIV | ENSG00000142208.19 | protein_coding | AKT1 | Yes | No | 207 | B0LPE5 P31749 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | AKT1 |
|---|---|
| DrugBank ID | DB01169 |
| Drug Name | Arsenic trioxide |
| Target ID | BE0000428 |
| UniProt ID | P31749 |
| Regulation Type | inducer |
| PubMed IDs | 12472888; 12529330; 15580309; 15916724; 16239170 |
| Citations | Fauconneau B, Petegnief V, Sanfeliu C, Piriou A, Planas AM: Induction of heat shock proteins (HSPs) by sodium arsenite in cultured astrocytes and reduction of hydrogen peroxide-induced cell death. J Neurochem. 2002 Dec;83(6):1338-48.@@He Z, Ma WY, Liu G, Zhang Y, Bode AM, Dong Z: Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1. J Biol Chem. 2003 Mar 21;278(12):10588-93. Epub 2003 Jan 14.@@Ivanov VN, Hei TK: Combined treatment with EGFR inhibitors and arsenite upregulated apoptosis in human EGFR-positive melanomas: a role of suppression of the PI3K-AKT pathway. Oncogene. 2005 Jan 20;24(4):616-26.@@Wang ZX, Jiang CS, Liu L, Wang XH, Jin HJ, Wu Q, Chen Q: The role of Akt on arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation. Cell Res. 2005 May;15(5):379-86.@@Tsou TC, Tsai FY, Hsieh YW, Li LA, Yeh SC, Chang LW: Arsenite induces endothelial cytotoxicity by down-regulation of vascular endothelial nitric oxide synthase. Toxicol Appl Pharmacol. 2005 Nov 1;208(3):277-84. |
| Groups | Approved; Investigational |
| Direct Classification | Metalloid oxides |
| SMILES | O=[As]O[As]=O |
| Pathways | |
| PharmGKB | PA448486 |
| ChEMBL | CHEMBL1200978 |
