| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10003136 | HBV | ENSG00000110092.4 | protein_coding | CCND1 | Yes | No | 595 | P24385 Q6FI00 |
| TVIS10022107 | HBV | ENSG00000110092.4 | protein_coding | CCND1 | Yes | No | 595 | P24385 Q6FI00 |
| TVIS10026610 | HBV | ENSG00000110092.4 | protein_coding | CCND1 | Yes | No | 595 | P24385 Q6FI00 |
| TVIS10039904 | HBV | ENSG00000110092.4 | protein_coding | CCND1 | Yes | No | 595 | P24385 Q6FI00 |
| TVIS10036484 | HBV | ENSG00000110092.4 | protein_coding | CCND1 | Yes | No | 595 | P24385 Q6FI00 |
| TVIS10039557 | HBV | ENSG00000110092.4 | protein_coding | CCND1 | Yes | No | 595 | P24385 Q6FI00 |
| TVIS10018229 | HBV | ENSG00000110092.4 | protein_coding | CCND1 | Yes | No | 595 | P24385 Q6FI00 |
| TVIS10018230 | HBV | ENSG00000110092.4 | protein_coding | CCND1 | Yes | No | 595 | P24385 Q6FI00 |
| TVIS10018231 | HBV | ENSG00000110092.4 | protein_coding | CCND1 | Yes | No | 595 | P24385 Q6FI00 |
| TVIS10018232 | HBV | ENSG00000110092.4 | protein_coding | CCND1 | Yes | No | 595 | P24385 Q6FI00 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CCND1 |
|---|---|
| DrugBank ID | DB01169 |
| Drug Name | Arsenic trioxide |
| Target ID | BE0001027 |
| UniProt ID | P24385 |
| Regulation Type | antagonist |
| PubMed IDs | 12480548; 16230390; 16387740; 17005224; 17370311 |
| Citations | Hyun Park W, Hee Cho Y, Won Jung C, Oh Park J, Kim K, Hyuck Im Y, Lee MH, Ki Kang W, Park K: Arsenic trioxide inhibits the growth of A498 renal cell carcinoma cells via cell cycle arrest or apoptosis. Biochem Biophys Res Commun. 2003 Jan 3;300(1):230-5.@@Ouyang W, Ma Q, Li J, Zhang D, Liu ZG, Rustgi AK, Huang C: Cyclin D1 induction through IkappaB kinase beta/nuclear factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes. Cancer Res. 2005 Oct 15;65(20):9287-93.@@Ouyang W, Li J, Ma Q, Huang C: Essential roles of PI-3K/Akt/IKKbeta/NFkappaB pathway in cyclin D1 induction by arsenite in JB6 Cl41 cells. Carcinogenesis. 2006 Apr;27(4):864-73. Epub 2005 Dec 29.@@Hwang BJ, Utti C, Steinberg M: Induction of cyclin D1 by submicromolar concentrations of arsenite in human epidermal keratinocytes. Toxicol Appl Pharmacol. 2006 Dec 1;217(2):161-7. Epub 2006 Aug 11.@@Ouyang W, Li J, Zhang D, Jiang BH, Huang DC: PI-3K/Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin D1. J Cell Biochem. 2007 Jul 1;101(4):969-78. |
| Groups | Approved; Investigational |
| Direct Classification | Metalloid oxides |
| SMILES | O=[As]O[As]=O |
| Pathways | |
| PharmGKB | PA448486 |
| ChEMBL | CHEMBL1200978 |
